Wednesday

7 Best Anti-Aging Beauty Secrets - Huffington Post

2015-08-07-1438980311-3181064-womanputtingoncreams.png
Photo credit: Fuse/Thinkstock

"I want to look older."
Said no one ever (no one over 20, that is).

Six weeks after my daughter was born, I saw them. Lines! Crow's feet! When did that happen? Of course, I'm proud of the life experiences that brought these lines. But that doesn't mean I won't put up a leeeetle bit of a fight to prevent them. Fortunately, we have many options now - from minimal to more involved treatments. Unfortunately, there is also a lot of hype and false claims around skin care products and anti-aging treatments. So, to tell us what really works, I asked two of my favorite dermatologists -- Amy Kim, MD, dermatologist at MetroDerm in Atlanta and founder of Baby Pibu Products, and Brian Raphael, MD, dermatologist and fellow at Skincare Physicians in Chestnut Hill, Massachusetts.

Consider this your à la carte menu for getting skin that's smoother than a baby's you-know-what.

What to do at home

1. Sunscreen: This one's a no-brainer. Daily use prevents wrinkles and age spots in the first place. News flash: most of us aren't using it correctly. You need to use a nickel-sized amount for your face and reapply every one to two hours to get nonstop protection. Make sure to use SPF 30 and above, broad spectrum. Don't want to mess up your makeup? Use a mineral powder with SPF for touchups (I keep this in my purse, and writing this just reminded me to reapply - so thank you!).

2. Retinoids: Every dermatologist I know swears by retinoids -- a vitamin A derivative that comes in cream or gel form. Retinoids work their magic by preventing collagen breakdown and stimulating skin cell turnover, giving you what Dr. Kim calls the "Retinoid Glow." They also prevent and treat acne (No one warned me that you could get both acne and wrinkles in adulthood. Whose idea was that?). Opt for the prescription form (often called tretinoin or Retin-A), as they are much more effective than over-the-counter forms. Most insurance companies won't cover retinoids and -- warning - they can be expensive. But one tube will last you at least two to three months and is a better investment than most expensive over-the-counter creams. Expect your skin to peel at first, and only use a small amount as directed. Those with sensitive skin may find that they can only tolerate it every other night.

3. Don't Over-Spend on Basic Moisturizers: Moisturizers are great for hydration, and are important as our skin ages. However, most of the claims for expensive/"high tech" moisturizers don't provide significant benefit over those from reputable drugstore brands and probably don't merit the additional splurge.

What to Consider at the Dermatologist

If you want to go a step further to brighten dull skin, reduce wrinkles and fade brown spots, here are the most effective options. Note: You do not have to do all of these to get positive results (in fact, please don't - look no further than certain celebrities to know that more is often less when it comes to cosmetic procedures).

4. Chemical Peels: To really reduce lines and improve the tone and texture of your skin, derms recommend getting a "medium depth peel" two to three times a year. The downside: You'll look (and feel) like you have a really bad sunburn for three to five days, so be sure not to schedule this before any important events. It's smart to get a chemical peel in the winter, since you have to avoid all sun exposure for a few days after treatment.

5. Laser Treatments: These treatments are newer and can be pretty expensive, but they do smooth the surface of the skin and reduce the appearance of wrinkles and lines. There are a variety of laser treatments, some which have a similar effect to peels, and others with greater intensity for older skin. Your dermatologist will be able to recommend which is better for your skin.

6. Botox: Dr. Raphael noted that Botox injections are helpful for not simply treating wrinkles, but preventing them in the first place. Botox is best for between the eyebrows, around the eyes and forehead and will need repeat injections every three to six months to maintain its effect. Botox placement can truly change your appearance (ever seen the permanently "shocked" people?) so if you do go this route, please avoid the "Discount Botox" places, and instead go to a board-certified dermatologist or plastic surgeon's clinic.

7. Fillers: These are effective for rejuvenating the lower portion of the face, says Dr. Raphael, especially around the nose and mouth, and under eye area. Depending on the type of fillers, they can last anywhere from six months to two to three years.

While these cosmetic fixes can improve your look from the outside, don't forget the impact that a healthy body has on your skin. Even in the ER, I can often tell someone's health status from their skin -- it reveals their nutrition and exercise habits, whether they smoke, have heart disease, get enough sleep and have good social support. Especially the last one - because having beauty doesn't guarantee you'll be happy and loved, but being happy and loving certainly ensures that you'll be beautiful.

This content originally appeared on Sharecare.com.
Listen to Dr. Darria interview Dr Kim on Sharecare Radio here.

Check out more articles by Dr. Darria Long Gillespie:

Busy Woman's Guide: 4 No-Fail Ways to Silence Your Inner Critic
6 Emergency Room Secrets

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Sunday

Going out in the sun? You need these anti-ageing SPFs - Telegraph.co.uk

Elizabeth Arden is well known for her beautiful restorative products, but we bet you haven't tried this yet.

The Day Intensive Anti-aging Moisture Cream has got SPF 30 in it, and works to minimise the ageing signs and existing sun damage - those old friends fine lines, wrinkles and discolouration.

With Advanced Idebenone technology, it's got powerful antioxidant protection against sun, smoke and pollution. Just lovely.

£115, johnlewis.com

2. Caudalie

Delightfully French, Caudalie's anti-aging facial suncare is packed full of goodness to prepare you for the sun.

Especially formulated for very hot sun, with its SPF 50, you'll still pick up a well-protected tan with this tube of joy.

It comes in SPF 30 too, in case 50 is too high for you.

£20, caudalie.com

3. SkinCeuticals

All of SkinCeuticals products are top notch, but the Ultra Facial Defense, with its SPF 50 protects skin from the rays that are known to cause premature skin ageing. You can't go wrong, really.

With its extremely efficient UV filters, this sunscreen helps to prevent UV induced collagen breakdown, they say, and we believe them.

£35, skinceuticals.co.uk

4. Creme de la Mer

The King Kong of moisturisers, this incredibly lovely lotion from Creme de la Mer does everything its meant to: prevent the appearance of lines, wrinkles and age spots.

With SPF 30, the skin is protected during exposure to the sun, and is duly firmed by Creme de la Mer's Reparative Face Sun Lotion.

£90, cremedelamer.co.uk

5. Murad

£49, lookfantastic.co.uk

Murad's anti-ageing moisturiser with its SPF 20 really packs a punch.

With collagen boosting ingredients and just enough sun protection inside, your skin is left fresh, toned and smooth, while age is asking to wait outside.

Read more

• The very best day creams

• Our favourite night creams

• The best hand creams going

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Wednesday

Top 5 Beauty Products Designed Specifically For Millennials - Hollywood Life

Anti Aging Products For Young Adults

Courtesy of Instagram

If you’re in your twenties, chances are you don’t pay much attention to beauty products advertised for their ‘anti-aging’ and ‘firming’ abilities. But to keep that youthful glow, it’s important to adopt a skincare routine right now.

While you may not be paying much attention to anti-agers, comb through the beauty aisle at your local drugstore or Sephora and you’ll probably notice that there aren’t a whole lot of anti-aging products for young adults out there. That’s why we put together our favorite skincare products just for millennials.

Celebrities like Taylor Swift and Rihanna may have access to all of the newest technology (and craziest trends), but when it comes to skincare in your 20s, it’s really all about taking preventative steps. But, in addition to using an SPF daily, avoiding smoking and practicing a healthy lifestyle, products like the Elizabeth Arden Flawless Future Line were specifically developed for younger skin.

To start incorporating anti-aging products into your skincare routine, start by applying Elizabeth Arden Flawless Future Powered By Ceramide Moisture Cream in the morning on just washed skin. In addition to Ceramides that protect against environmental factors, the cream also contains SPF 30, which dermatologists stress should to be worn every single day (yes, even in the winter).

At night is when you can start to work in products that are a bit stronger. If you’re in your late 20s or early 30s and want something that’s more aggressive towards fine lines, Dermalogica Overnight Retinol Repair lets you ease your way into the powerful, popular world of retinol. The repair cream also comes with a buffer cream that gets mixed together so your skin can build up to regular retinol use without irritation. If you’re in your early 20s and aren’t quite ready for retinol, try using Origins Original Skin Renewal Serum With Willowherb, which contains algae to shrink pores and chestnut seed extract and willowherb to even skin tone.

Anti-Aging Products For Young Adults â€" Skincare Products Designed For Millennials

With your serum set, make sure to apply an eye cream like Caudalie Vinexpert Anti-Aging Eye & Lip Serum, which contains the powerful anti-aging antioxidant, resveratrol. For a once a week boost to skin, use a hydrating mask like GlamGlow Thirsty Mud Mask. The mask can be used on the face, neck and chest, and it contains ingredients like hyaluronic acid and coconut to lock in moisture and condition the skin.

Do you have a skincare routine in place, HollywoodLifers? Which product are you most excited to give a try?

â€" Marissa DeSantis

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Monday

Beware: Anti-aging cream, food can have opposite effect on young people - Pulse Nigeria

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A new study has said anti-aging creams which are rich in antioxidants could infact be harmful to younger people's skin.

Antioxidants are portrayed as beneficial because they prevent free-radicals from damaging cells, but a new study suggests that in young people free radicals are essential for skin healing and healthy regeneration.

Scientists in the United States bred mice which produced excess free radicals to mirror the effects in humans, while they expected to see accelerated ageing, but instead they found the animal's skin improved.

The mice in the study aged and their skin cells became increasingly damaged by free radicals, eventually stopping dividing completely.

According to Professor Judith Campisi at the Buck Institute for Research on Ageing, in California, it's essential to look across the entire lifespan when examining mechanisms implicated in the aging process as mechanisms that benefit us when we're young, cause problems as we age.

She further said that said eating or applying large amounts of antioxidants might have damaging effects to the skin in young people because free radicals are necessary to keep skin regenerating effectively.

Free radicals are atoms which have missing electrons and so steal electrons from other healthy atoms, which causes cell damage in a process known as oxidation.

Antioxidants essentially ‘donate’ their electrons to neutralise free radicals and stop them from causing any more harm.

While health experts and beauticians have long recommended eating foods rich in antioxidants, it appears that it may only work in older age.

The research was published in the journal Proceedings of the National Academy of Sciences.

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Saturday

Wonder or rip-off? How to buy the perfect anti-wrinkle cream - WDSU New Orleans

TRULY WORK AS ADVERTISED. DR. HEBERT: THERE ARE A LOT OF COMMERCIALS ABOUT MIRACLE WRINKLE CREAMS. IF YOU'RE GOING TO PAY A LOT OF MONEY FOR AN ANTI-WRINKLE CREAM, YOU WANT TO KNOW THAT ITS GOING TO WORK. UNFORTUNATELY, WRINKLE CREAMS DO NOT COME WITH GUARANTEES. THE FDA CLASSIFIES CREAMS AND LOTIONS AS COSMETICS, NOT MEDICINE, WHICH MEANS THEY ARE NOT AS CAREFULLY TESTED FOR SAFETY AND EFFECTIVENESS AS MEDICAL ANTI-AGING TREATMENTS, LIKE BOTOX SHOTS. MOST DOCTORS AGREE THAT IF ANTI-WRINKLE CREAMS COULD HEAL SKIN LIKE MEDICAL PROCEDURES CAN, THEY WOULD BE CLASSIFIED AS DRUGS, NOT AS COSMETICS. THAT IS THE BAD NEWS. BUT DO NOT FRET -- THE GOOD NEWS IS THAT THE EFFECTIVENESS OF ANY PRODUCT DEPENDS ON ITS ACTIVE INGREDIENTS AND THERE IS EVIDENCE TO SUGGEST THAT CERTAIN INGREDIENTS IN ANTI-WRINKLE CREAMS WORK. A FAVORITE, PENTAPEPTIDES, ARE COMPOUNDS THAT SERVE AS CHEMICAL MESSENGERS IN THE BODY. ACCORDING TO RESEARCH CENTERED ON WOUND-HEALING, PENTAPEPTIDES ARE CRUCIAL IN ENCOURAGING CELLS TO CREATE MORE COLLAGEN. BECAUSE COLLAGEN IS THE SUPPORT STRUCTURE THAT GIVES SKIN ITS YOUNG, FIRM LOOK, WE ALL WANT LOTS OF IT. SADLY, THOUGH, AGING CAUSES OUR COLLAGEN LEVELS TO DECREASE, WHICH LEADS TO SAGGING AND WRINKLES. THATS WHY COLLAGEN-CREATING PENTAPEPTIDES ARE A COMMON INGREDIENT IN ANTI-WRINKLE CREAMS. OTHER ANTI-WRINKLE CREAMS MAY WORK BY INCLUDING RETINOL, A DERIVATIVE OF VITAMIN A. RETINOL IS AN ANTIOXIDANT, WHICH MEANS IT STOPS UNSTABLE OXYGEN MOLECULES FROM HARMING SKIN CELLS AND CAUSING WRINKLES. THE MOST EFFECTIVE, STRONGEST FORM OF RETINOL, CALLED TRETINOIN, IS AVAILABLE ONLY VIA PRESCRIPTIONS LIKE RETIN-A AND RENOVA. WEAKER CONCENTRATIONS ARE SOLD OVER-THE-COUNTER IN CERTAIN ANTI-WRINKLE CREAMS, AND THEY MAY ALSO BE EFFECTIVE OVER TIME. ANOTHER POPULAR INGREDIENT IN WRINKLE CREAMS IS REALLY JUST A FANCY VERSION OF VITAMIN B3, OR NIACIN. VARIATIONS OF NIACIN COULD MAKE THE TOP LAYER OF THE SKIN THICKER, IN TURN IMPROVING ITS ABILITY TO RETAIN MOISTURE, AND, THANKFULLY, REDUCING WRINKLES. SO, THE MILLION-DOLLAR QUESTION -- DO ALL THESE INGREDIENTS MEAN THAT ANTI-WRINKLE CREAMS ARE A WONDER OR A RIP-OFF? THE ANSWER LIES SOMEWHERE IN BETWEEN. IF YOU'RE LOOKING FOR TREATMENT FOR MILD OR PREVENTATIVE AGING, IF YOU DONT LIKE THE PRICE TAG OF MEDICAL TREATMENTS, AND IF YOU DO NOT MIND WAITING FOR RESULTS -- THEN YES, ANTI-WRINKLE CREAMS ARE A GOOD OPTION FOR YOU. IF YOUR ISSUES ARE MORE SEVERE, HOWEVER, AND IF YOU WANT TO SEE CHANGES NOW, DISCUSS THE LATEST PRESCRIPTION TREATMENTS WITH YOUR DERMATOLOGIST.

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Wednesday

An Anti-Aging Pill Is Still A Long Way Off - Science 2.0

Last month a team of doctors and scientists made the case to regulators at the Food and Drug Administration (FDA) to consider approving anti-aging drugs as a new pharmaceutical class.

Such a designation would treat aging as disease rather than a natural process, potentially opening the door to government funding for anti-aging drug trials.

To some, such a drug may seem impossible. Yet, the physiologic basis for it exists. In fact, some candidate drugs, such as metformin, used to treat diabetes, are already being safely used for treating other conditions. Many scientists believe that designing an anti-aging medication is a matter of “when,” not “if.”

Yet the very idea of a quick-fix pill for stopping, and perhaps even reversing, nature’s intricate biologic clock thus far has proven to be a hubristic notion. There is much we need to learn about how the aging process works. And while some drugs have shown promise as anti-aging treatments in the lab, we don’t know how well, or even if, they will work in humans.

What actually happens to us when we age?

Aging remains a mystery. While the visible changes of gray hair and wrinkles are unmistakable, what goes on inside your body is less clear. According to leading theories, aging is an accumulation of damage inside your cells, the building blocks of your tissues.

Cells continually receive cues from your body and the environment that can accelerate age-driving processes such as oxidative damage and inflammation. These processes are interdependent â€" woven in a complex maze that is perplexing and daunting for researchers.

Rather than trying to extend life by individually targeting prevention and treatment of common age-related diseases such as heart disease, stroke and cancer, scientists are looking for a “master control switch” that can regulate the divergent and overlapping pathways that contribute to aging itself.

Since aging is the biggest risk factor for developing such diseases, an anti-aging medication that can flip this switch would theoretically not only slow or stop aging but would also defer many diseases associated with aging.

And that is what some of the drugs scientists are investigating may be able to do.

A drug from dirt: rapamcyin

Discovered more than 30 years ago in soil samples from the Polynesian island of Rapa Nui, rapamcyin is perhaps the leading contender in the race for the first anti-aging drug.

It is already FDA-approved for use as an immune suppressant that reduces organ rejection in kidney transplants. It is also used to treat certain cancers, since it can stop cells from growing.

In 2009, researchers made another observation about this versatile drug: when fed to mice at the equivalent age in humans of 60 years, it gave them a boost in life expectancy â€" an impressive 38% in female mice and 28% in male mice. It has also been proven to extend lifespan in yeast, worms and fruit flies.

Rapamycin’s ability to extend life in these animals comes from its ability to block a cell’s mTOR pathway â€" which gets its name for being the “mammalian target of rapamycin.” mTOR controls many diverse processes that affect how a cell grows and proliferates. It is one of the master switches researchers have been hoping to find â€" a unifying pathway in all of our cells that can control the rate of aging as well as the risk of diseases such as heart disease, cancer and Alzheimer’s dementia.

mTOR gets its cues from hormones as well as nutrients. When food is abundant, mTOR signals cells to absorb nutrients and grow. The very process of growing and metabolizing food, however, creates byproducts that stress and age cells.

Restrict calories and mTOR signals cells to stop growing â€" and hence slows aging. What makes rapamycin attractive as an anti-aging drug is that it can block the mTOR pathway without the need for restricting calories.


We don’t know much about how resveratrol affects humans. Grapes via www.shutterstock.com.

Grapes, nuts and resveratrol

Finding a drug that can mimic calorie restriction â€" which otherwise may not be practical or sustainable â€" has become a focal point for anti-aging research.

Mostly an experimental tool, calorie-restricted diets are ones that reduce calorie consumption by 30%â€"40% while still including all needed nutrients.

It was discovered as a way to extend lifespan in the 1930s when Clive McCay, a nutritionist at Cornell University, incidentally observed that rats that were on calorie-restricted diets were living considerably longer than their litter mates. Since then, calorie restriction has been proven to extend life in yeast, worms, flies, certain strains of mice and some nonhuman primates.

Exactly how calorie restriction extends longevity isn’t known, but is likely to involve reducing stress inside cells caused by harmful byproducts, called free radicals, that are produced in the process of breaking down food.

Blocking the mTOR pathway is one way to mimic calorie restriction a la rapamycin. David Sinclair, an Australian researcher now based at Harvard, has been studying another pathway: a group of genes called sirtuins. Similar to mTOR, one of these genes, SIRT1, may be a unifying pathway, or master regulator, with the potential to extend lifespan and prevent a slew of age-related diseases.

SIRT1 is switched on by calorie restriction. In 2003, Sinclair and his colleagues made the discovery that resveratrol, a natural compound found in grapes, red wine and certain nuts, can also turn on SIRT1 â€" and extend lifespan in yeast by 70%.

Subsequently given to mice on a high-fat diet, resveratrol-fed mice lived longer than their non-resveratrol-fed counterparts.

However, given to mice on a regular diet, resveratrol did not show the same impressive life-extending results. This, along with other studies, has raised questions about resveratrol’s anti-aging benefit.

Although preliminary human studies on the anti-aging benefit of resveratrol are promising, resveratrol thus far has mostly been extensively studied in laboratory and animal studies. There have been over 4,000 studies on resveratrol, but only a handful have been done in humans, so it is too early to know if resveratrol will have an anti-aging and disease preventing benefit for us.

While research continues on resveratrol, over a hundred other drugs have been studied that can activate sirtuin genes â€" with the leading three currently being studied in human trials.


Some drugs might target telomeres. Telomeres via www.shutterstock.com.

Genetically engineering longevity

Searching for drugs that can flip a master-switch longevity gene is one approach to extending lifespan. Researchers are also looking at other ways of manipulating genes.

Telomeres, caps at the end of chromosomes that shorten every time a cell divides, are one potential target. When telomeres are dwindled down, a cell can no longer divide, and dies.

Ronald DePinho and his group at the Dana-Farber Cancer Institute in Boston have been studying how manipulating telomerase, an enzyme that can preserve these tips, affects mice.

Other researchers are looking for a drug that could ramp up telomerase, in particular as a potential treatment for people with rare disorders that cause premature aging. But there is a caveat to this approach: ramping up telomeres could potentially encourage cells to divide indefinitely and become tumor cells.

Another longevity gene that is being explored is the Klotho gene. Klotho is an aging suppressor gene. Researchers have discovered that mice without Klotho age faster and are more prone to age-related diseases. It’s much too early to know if manipulating Klotho will affect human longevity.

Of mice and men

These drugs are all amazing and groundbreaking, yes â€" but not in humans. The role of mTOR, sirtuins, telomerase and Klotho in human aging is more nuanced and complex than in lab animal studies. Making the leap from mice to men â€" and realizing the futuristic vision of communities full of active, healthy, independent centenarians â€" will require overcoming many hurdles.

Rapamycin’s life-extending ability in invertebrates and mice is encouraging but it remains to be seen whether it will have the same longevity benefit in humans. Rapamycin is also not without side effects. It can raise cholesterol and blood sugar.

And, a 2012 study of long-term rapamycin treatment in mice reported increased incidence of cataracts and testicular degeneration â€" not very sexy for a longevity drug.

Another unresolved question is whether rapamycin would suppress the immune system of healthy people, which may slow aging while making people susceptible to otherwise innocuous bacteria and viruses.

Despite widespread acceptance, scientists do not yet know if long-term calorie restriction is nutritionally safe or effective in humans. Although encouraging in lab animal models, calorie restriction doesn’t seem to have the same life extending benefit in non-lab, or wild, mice. Studies in nonhuman primates and humans are under way, but it will be years until we know the results.

While the race to find the first true anti-aging pill â€" and our obsession with eternal youth â€" continues, it is easy to overlook that we already have a proven “breakthrough” for slowing aging and delaying or preventing age-related diseases: following a balanced diet full of fruits, vegetables and whole grains and getting regular physical activity. And, all the side effects, I promise, are ones you will enjoy.The Conversation

Sharon Horesh Bergquist is Physician, teacher, researcher in preventive medicine and healthy aging at Emory University. This article was originally published on The Conversation. Read the original article. Top image: Shutterstock

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Tuesday

Despite research breakthroughs, an anti-aging pill is still a long way off - The Conversation US

Last month a team of doctors and scientists made the case to regulators at the Food and Drug Administration (FDA) to consider approving anti-aging drugs as a new pharmaceutical class. Such a designation would treat aging as disease rather than a natural process, potentially opening the door to government funding for anti-aging drug trials.

To some, such a drug may seem impossible. Yet, the physiologic basis for it exists. In fact, some candidate drugs, such as metformin, used to treat diabetes, are already being safely used for treating other conditions. Many scientists believe that designing an anti-aging medication is a matter of “when,” not “if.”

Yet the very idea of a quick-fix pill for stopping, and perhaps even reversing, nature’s intricate biologic clock thus far has proven to be a hubristic notion. There is much we need to learn about how the aging process works. And while some drugs have shown promise as anti-aging treatments in the lab, we don’t know how well, or even if, they will work in humans.

What actually happens to us when we age?

Aging remains a mystery. While the visible changes of gray hair and wrinkles are unmistakable, what goes on inside your body is less clear. According to leading theories, aging is an accumulation of damage inside your cells, the building blocks of your tissues.

Cells continually receive cues from your body and the environment that can accelerate age-driving processes such as oxidative damage and inflammation. These processes are interdependent â€" woven in a complex maze that is perplexing and daunting for researchers.

Rather than trying to extend life by individually targeting prevention and treatment of common age-related diseases such as heart disease, stroke and cancer, scientists are looking for a “master control switch” that can regulate the divergent and overlapping pathways that contribute to aging itself.

Since aging is the biggest risk factor for developing such diseases, an anti-aging medication that can flip this switch would theoretically not only slow or stop aging but would also defer many diseases associated with aging.

And that is what some of the drugs scientists are investigating may be able to do.

A drug from dirt: rapamcyin

Discovered more than 30 years ago in soil samples from the Polynesian island of Rapa Nui, rapamcyin is perhaps the leading contender in the race for the first anti-aging drug.

It is already FDA-approved for use as an immune suppressant that reduces organ rejection in kidney transplants. It is also used to treat certain cancers, since it can stop cells from growing.

In 2009, researchers made another observation about this versatile drug: when fed to mice at the equivalent age in humans of 60 years, it gave them a boost in life expectancy â€" an impressive 38% in female mice and 28% in male mice. It has also been proven to extend lifespan in yeast, worms and fruit flies.

Rapamycin’s ability to extend life in these animals comes from its ability to block a cell’s mTOR pathway â€" which gets its name for being the “mammalian target of rapamycin.” mTOR controls many diverse processes that affect how a cell grows and proliferates. It is one of the master switches researchers have been hoping to find â€" a unifying pathway in all of our cells that can control the rate of aging as well as the risk of diseases such as heart disease, cancer and Alzheimer’s dementia.

mTOR gets its cues from hormones as well as nutrients. When food is abundant, mTOR signals cells to absorb nutrients and grow. The very process of growing and metabolizing food, however, creates byproducts that stress and age cells.

Restrict calories and mTOR signals cells to stop growing â€" and hence slows aging. What makes rapamycin attractive as an anti-aging drug is that it can block the mTOR pathway without the need for restricting calories.

We don’t know much about how resveratrol affects humans. Grapes via www.shutterstock.com.

Grapes, nuts and resveratrol

Finding a drug that can mimic calorie restriction â€" which otherwise may not be practical or sustainable â€" has become a focal point for anti-aging research.

Mostly an experimental tool, calorie-restricted diets are ones that reduce calorie consumption by 30%â€"40% while still including all needed nutrients.

It was discovered as a way to extend lifespan in the 1930s when Clive McCay, a nutritionist at Cornell University, incidentally observed that rats that were on calorie-restricted diets were living considerably longer than their litter mates. Since then, calorie restriction has been proven to extend life in yeast, worms, flies, certain strains of mice and some nonhuman primates.

Exactly how calorie restriction extends longevity isn’t known, but is likely to involve reducing stress inside cells caused by harmful byproducts, called free radicals, that are produced in the process of breaking down food.

Blocking the mTOR pathway is one way to mimic calorie restriction a la rapamycin. David Sinclair, an Australian researcher now based at Harvard, has been studying another pathway: a group of genes called sirtuins. Similar to mTOR, one of these genes, SIRT1, may be a unifying pathway, or master regulator, with the potential to extend lifespan and prevent a slew of age-related diseases.

SIRT1 is switched on by calorie restriction. In 2003, Sinclair and his colleagues made the discovery that resveratrol, a natural compound found in grapes, red wine and certain nuts, can also turn on SIRT1 â€" and extend lifespan in yeast by 70%.

Subsequently given to mice on a high-fat diet, resveratrol-fed mice lived longer than their non-resveratrol-fed counterparts.

However, given to mice on a regular diet, resveratrol did not show the same impressive life-extending results. This, along with other studies, has raised questions about resveratrol’s anti-aging benefit.

Although preliminary human studies on the anti-aging benefit of resveratrol are promising, resveratrol thus far has mostly been extensively studied in laboratory and animal studies. There have been over 4,000 studies on resveratrol, but only a handful have been done in humans, so it is too early to know if resveratrol will have an anti-aging and disease preventing benefit for us.

While research continues on resveratrol, over a hundred other drugs have been studied that can activate sirtuin genes â€" with the leading three currently being studied in human trials.

Some drugs might target telomeres. Telomeres via www.shutterstock.com.

Genetically engineering longevity

Searching for drugs that can flip a master-switch longevity gene is one approach to extending lifespan. Researchers are also looking at other ways of manipulating genes.

Telomeres, caps at the end of chromosomes that shorten every time a cell divides, are one potential target. When telomeres are dwindled down, a cell can no longer divide, and dies.

Ronald DePinho and his group at the Dana-Farber Cancer Institute in Boston have been studying how manipulating telomerase, an enzyme that can preserve these tips, affects mice.

Other researchers are looking for a drug that could ramp up telomerase, in particular as a potential treatment for people with rare disorders that cause premature aging. But there is a caveat to this approach: ramping up telomeres could potentially encourage cells to divide indefinitely and become tumor cells.

Another longevity gene that is being explored is the Klotho gene. Klotho is an aging suppressor gene. Researchers have discovered that mice without Klotho age faster and are more prone to age-related diseases. It’s much too early to know if manipulating Klotho will affect human longevity.

Of mice and men

These drugs are all amazing and groundbreaking, yes â€" but not in humans. The role of mTOR, sirtuins, telomerase and Klotho in human aging is more nuanced and complex than in lab animal studies. Making the leap from mice to men â€" and realizing the futuristic vision of communities full of active, healthy, independent centenarians â€" will require overcoming many hurdles.

Rapamycin’s life-extending ability in invertebrates and mice is encouraging but it remains to be seen whether it will have the same longevity benefit in humans. Rapamycin is also not without side effects. It can raise cholesterol and blood sugar.

And, a 2012 study of long-term rapamycin treatment in mice reported increased incidence of cataracts and testicular degeneration â€" not very sexy for a longevity drug.

Another unresolved question is whether rapamycin would suppress the immune system of healthy people, which may slow aging while making people susceptible to otherwise innocuous bacteria and viruses.

Despite widespread acceptance, scientists do not yet know if long-term calorie restriction is nutritionally safe or effective in humans. Although encouraging in lab animal models, calorie restriction doesn’t seem to have the same life extending benefit in non-lab, or wild, mice. Studies in nonhuman primates and humans are under way, but it will be years until we know the results.

While the race to find the first true anti-aging pill â€" and our obsession with eternal youth â€" continues, it is easy to overlook that we already have a proven “breakthrough” for slowing aging and delaying or preventing age-related diseases: following a balanced diet full of fruits, vegetables and whole grains and getting regular physical activity. And, all the side effects, I promise, are ones you will enjoy.

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Monday

Health Matters for week of July 27: Ian Ziering's anti-aging secrets, and more ... - The Providence Journal

Anti-aging tips
Reading With Robin hosts "Read, Relax and Rejuvenate" with Ian Ziering Tuesday at 7 pm at Panera Bread, 1000 Division Rd., East Greenwich. Ziering will share his anti-aging secrets and how he uses natural essential oils for sleep, stress, unwinding, headaches, anti-aging, energy and focus, health, shortening and preventing colds, muscle fatigue and aches and pains. The program fee is $25 and includes lavender essential oil. Register at eventbrite.com/e/read-relax-rejuvenate-with-ian-ziering-tickets-17885579249.
Stroke support
The Stroke Center at Kent Hospital, 455 Toll Gate Rd., Warwick, hosts a stroke support meeting Wednesday at 1 p.m. in the Trowbridge Building, adjacent to the hospital, in rooms 102/103. A guest speaker will discuss concerns regarding stroke. All those who have survived or are at risk for a stroke and caregivers for stroke survivors are encouraged to attend. Contact Susan Moore at 737-7010, ext. 35510 or email smoore@kentri.org.
Miracle Treat Day
Two local Dairy Queen locations will host Miracle Treat Day Thursday to raise funds for Hasbro Children's Hospital as part of the company's partnership with Children's Miracle Network Hospitals. Dairy Queen in the Providence Place mall and at 389 North Washington St., North Attleboro, will donate $1 or more from every Blizzard Treat sold to Hasbro Children's Hospital. In addition, customers can contribute to the hospital by purchasing a paper "Miracle Balloon" at the register. hasbrochildrenshospital.org.
Full moon yoga
All That Matters Yoga and Holistic Health Center offers a full moon beach yoga session Friday at 7:45 p.m. at South Kingstown Beach, Matunuck Beach Road, South Kingstown. The cost is $18 and registration is encouraged. 374-4343; allthatmatters.com.
Victim assistance
Family Service of Rhode Island and the Roger Williams University School of Justice Studies present the Rhode Island State Victim Assistance Academy on five consecutive Fridays, July 31 through Aug. 28, at Roger Williams University Baypoint Inn & Conference Center, 144 Anthony Rd., Portsmouth. Topics include homicide victim response, elder victims, childhood victimization, victims' issues in mental health, ethics, the justice system, working with sex trafficking victims and victimization in the military. 331-1350, ext. 3200; familyserviceri.org.
5K road race
The Runaways Running Club's 13th "Runaways Runaround" 5K Road Race will be held Sunday at 9 a.m. The race begins at Town Hall, 43 South Washington St., North Attleboro, with the course looping through North Attleboro. Registration fee is $25 online and $30 on race day. Proceeds benefit Community VNA's Hospice and Palliative Care Program. For more information, visit the club's website, runawaysclub.org, or call (508) 339-0147. Register at signmeup.com/105324. 
Arthritis fundraiser
The 12th annual Edd Pedro's "Fight for a Cure" Wiffleball Tournament takes place Sunday, Aug. 9, 9 a.m. to 5 p.m., at Slater Park, Pawtucket, with teams still needed for youth, adult fun and adult competitive divisions. The event will also include carnival games, music, food and a possible appearance by Dennis "Oil Can" Boyd. A raffle with more than 100 prizes including tickets to New England Patriots and Boston Red Sox games, a fishing trip for four and sports memorabilia, will be held. All proceeds benefit the Arthritis Foundation with a focus on juvenile arthritis. To register a team, become a sponsor or for other information, visit wiffleman.com or email Edd Pedro at edd@wiffleman.com.
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Sunday

Is Anti-Aging All In The Mind? - Longevity LIVE

You really are as old â€" or as young â€" as you look and feel. According to Dr Michael Brickey, author of Defy Aging and 52 Baby Steps to Grow Young, only 20% to 30% of longevity is genetic â€" therefore 70% to 80% depends on what we think and the lifestyle choices we make. One of the biggest factors to keeping our youthful appearance, says Brickey, is psychological: our attitudes, beliefs and coping skills. Dr Hannetjie van Zyl-Edeling, author of Over the Moon! A guide to Positive Ageing, concurs. She describes the four different ages: chronological, emotional, biological and psychological.

Chronological age:

This is our age in years, and one we cannot change.

Happy Couple

Emotional age:

This is how we behave â€" and it is influenced by our life experiences.

anti-aging

Biological age:

Our health and the inner workings of our body determine our biological age. But we can, to a large extent, choose our biological age, she says. “Both Dr Deepak Chopra, a very well-known endocrinologist and spiritual author, and Professor Willem Serfontein, a South African medical researcher, are among many strong voices from research who say that it is perfectly possible for us to choose a biological age that is up to 15 years younger than our chronological age.”

Healthy

Psychological age:

This is how old we feel we are. It is influenced by our mindset and beliefs. “By taking control of our beliefs and feelings, we can significantly improve our psychological age and our internal programming that it is ruled by.” As Brickey explains, our life spans are increasing. “Science, particularly genetic engineering and tissue engineering, are likely to continue to bring huge gains in longevity.”

children playing video games

Anti-aging itself is all-encompassing, and can be implemented from as early as our 20s. It addresses how to prevent, slow or reverse the effects of aging, including how we look, how we feel, and our attitude, he says.

According to research compiled by the International Dermal Institute, and Dr Diana Howard, Annet King and Dermalogica founder Jane Wurwand, aging is one of the hottest topics in the skincare market. IBIS World Market Research estimates the anti-aging industry to generate $291,9 billion this year.

The idea is formulating that anti-aging programmes are actually healthcare, rather than an act of vanity. Skincare marketers are moving away from terms such as luxury, pampering or indulgence â€" and towards science and research based health and skincare. The No 1 aging concern, say the authors, remains wrinkles. And many skincare products will promise to reduce or even remove these telltale signs of aging. However, warns Howard and co, only a limited number of ingredients will truly address the signs of aging, and unfortunately, nothing short of cosmetic surgery can really erase a wrinkle.

The good news is that research (and science) has found that retinol (vitamin A), ascorbic acid (vitamin C) and various peptides (such as palmitoyl pentapeptide, palmitoyl tripeptide, and oligopeptides) all show positive effects in stimulating collagen to help to smooth and retexture aging skin. .e buzzword for all skin types is hydration, and this is particularly important when it comes to the cooler, drier months.

Ultimately, as your skin is your biggest organ, it is vital to ensure that you feel comfortable, beautiful and confident in it.

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Thursday

Anti-Aging Products Market in Asia, Europe, and South America is Expected to ... - GlobeNewswire (press release)

Albany, NY, July 23, 2015 (GLOBE NEWSWIRE) -- According to a new market report published by Transparency Market Research "Asia, Europe, and South America Anti-aging Market - Industry Analysis, Size, Share,  Growth, Trends and Forecast 2014 - 2020 ", Asia anti-aging market was valued at USD 15.28 billion in 2012 and is expected to grow at a CAGR of 9.3% from 2014 to 2020, to reach an estimated value of USD 30.92 billion in 2020.

Aging is a natural process of physiological changes in a person that are observed over a period of time. Presently, increasing awareness among the general population to retain youth, health and beauty is the chief factor driving the global anti-aging market. While other factors such as rising geriatric population, and stringent regulations are supporting the growth of anti-aging market. In addition, rising awareness of aging signs in generation X and generation Y are the prime factors supporting the growth of anti-aging market.

Browse Market Research Report on Anti-aging Products Market: http://www.transparencymarketresearch.com/asia-europe-south-america-anti-aging-market.html

Products segment accounted for the largest market share in the overall anti-aging market in Asia, Europe and South America in 2013. Factors such as wide availability of anti-aging products in the market, affordable prices coupled with high awareness are fueling the growth of the products segment of the anti-aging market in Asia, Europe, and South America. While on the other hand, presence of large number of players operating in the anti-aging products segment is the prime factor in challenging the growth of the market.

Browse Press Release of Anti-aging Products Market: http://www.transparencymarketresearch.com/pressrelease/asia-europe-south-america-anti-aging-market.htm

Anti-wrinkle products was observed to be the largest segment of anti-aging products market in Asia in 2013. Factors such as availability of wide variety of anti-wrinkle products and increasing awareness due to rise in promotional campaigns are the key factors fueling the demand for these products in Asia. Moreover, wrinkles and grey hair are the common signs of aging that start appearing prominently at the age of 30 years. It has been estimated that around 40% of the Asian population is in the age group of 25 to 50 years. Thus, demand for anti-wrinkle products is high in Asia. Considering all the above factors, anti-wrinkle products segment accounted for the largest market in the overall anti-aging market in Asia in 2013. Similarly, anti-wrinkle segment was also leading the Europe anti-aging products market in 2013. Dominance of this product segment was majorly due to high awareness and availability of wide variety of anti-wrinkle products at affordable cost in Europe.

Get Sample Report Copy of Anti-aging Products Market: http://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=5021

In 2013, laser aesthetic devices were observed to be the largest devices segment in Europe, due to its efficient and permanent effect along with peaking demand for cost efficient portable devices. Increasing demand for non-invasive treatments, rising obese population and introduction of portable anti-cellulite devices would propel the market growth during the forecast period from 2014 to 2020. While on the other hand, laser aesthetic devices dominated the Asia anti-aging devices market in 2013, owing to prolonged and permanent effect and time efficient option for dermal care. In addition, increasing obese population, rise in preference for portable devices and demand for non-invasive anti-cellulite devices would propel the growth of the laser aesthetic devices market during the forecast period from 2014 to 2020.

Browse Article of Anti-aging Products and Services: http://www.transparencymarketresearch.com/article/asia-europe-south-america-anti-aging-market.htm

Anti-aging services market in South America accounted for USD 1,466.7 million in 2012. Factors such as high accessibility coupled with rising awareness are accentuating the rise of anti-aging services in South America. Hair restoration treatment services segment dominated the South America anti-aging services market in 2013. The dominance of this market segment was majorly due to increasing preference for minimally invasive surgeries and availability of skilled workforce in South America. While on the other hand, stringent regulatory guidelines are some of the factors challenging the growth of the hair restoration treatment market in South America.

Other Reports Published by Transparency Market Research :

Some of the major players contributing to the Europe, Asia and South America Anti-aging market include Allergan, Inc., Alma Lasers Ltd., Beiersdorf AG, Coty, Inc., Cynosure, Inc., L'Oreal SA, Lumenis Ltd., PhotoMedex, Inc., Personal Microderm (PMD) (Age Sciences, Inc.), and Solta Medical, Inc.

Asia, Europe and South America Anti-aging market has been segmented as follows:

Asia, Europe and South America Anti-aging market, by Products Type

  • UV Absorbers
  • Dermal Fillers
  • Botox
  • Anti-stretchmark Products
  • Hair Color
  • Anti-wrinkle Products

Asia, Europe and South America Anti-aging market, by Services

  • Anti-pigmentation Therapy,
  • Anti-adult Acne Therapy
  • Breast Augmentation
  • Liposuction
  • Abdominoplasty
  • Chemical Peel
  • Eye Lid Surgery
  • Hair Restoration Therapy
  • Sclerotherapy

Asia, Europe and South America Anti-aging market, by Devices Type

  • Anti-cellulite Treatment Devices
  • Microdermabrasion Devices
  • Laser Aesthetic Devices
  • Radio Frequency Devices

Asia, Europe and South America Anti-aging market, by Country

  • China
  • India
  • Japan
  • South Korea
  • Germany
  • U.K.
  • Spain
  • Italy
  • France
  • Brazil

Browse Upcoming Market Research Reports:

Browse All Other Medical Market Research Reports: http://www.transparencymarketresearch.com/medical-devices-market-reports-6.html

About Us:

Transparency Market Research (TMR) is a U.S. based provider of syndicated research, customized research, and consulting services. TMR's global and regional market intelligence coverage includes industries such as pharmaceutical, chemicals and materials, technology and media, food and beverages, and consumer goods, among others. Each TMR research report provides clients with a 360-degree view of the market with statistical forecasts, competitive landscape, detailed segmentation, key trends, and strategic recommendations.

Mr. Nachiket Ghumare    90 State Street, Suite 700  Albany, NY 12207  Tel: +1-518-618-1030  USA - Canada Toll Free: 866-552-3453  Email: sales@transparencymarketresearch.com  Website: http://www.transparencymarketresearch.com  Blog: http://www.tmrblog.com/  
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Here's Everything You Need to Know About Anti-Aging—for Your Hair - Allure Magazine (blog)

aging-hair.jpg
Chances are your mother has a lock of your baby hair. The odds you've asked for a lock of her hair? Slim. (We hope.) With age, hair loses its luster, not to mention its strength, color, and density. We asked Nicole Rogers, an assistant clinical professor of dermatology at Tulane University School of Medicine in New Orleans, how to minimize the damage.

What happens to hair as we age? "The majority of people will notice allover thinning as early as their 40s because of an age-related decline in the overall diameter of the hair shaft. Pattern hair loss can happen at any age; thin, wispy hairs replace the thick growth on the crown. This affects roughly 40 to 50 percent of women. Topical minoxidil [a.k.a. Rogaine] can help both."

Why does the texture start to change? "Each shaft of hair is surrounded by a cuticle, which under a microscope looks like overlapping shingles on a roof. This is what gives hair strength and shine. When you're young, the cuticle remains intact, but eventually, gaps start to open up between the shingles. That leaves hair vulnerable to sun, heat, and other damage that weakens the fibers and frays the ends."

What can we do to protect our hair? "I tell patients to wear a hat every time they're in the sun, especially if they exposed for more than 30 minutes. If you can't wear a hat, there are great leave-in products that coat the hair shaft with silicone or dimethiconeâ€"the same things you use with curling irons and hair-dryers."

True or false: If you pluck a gray hair, two will grow back. "False! Gray hair runs in families, so if your grandmothers had white hair, you'll probably get it, too, and at about the same age. At first, the follicle stops absorbing pigment, for reasons we don't understand, and then the pigment-producing cells shut down entirely. There's no pill or herbal supplement to reverse this process, but you can protect yourself from another cause of graying. You know our presidents go rapidly gray during their time in the White House? That's because of oxidative stress, and there's some evidence that eating antioxidant foodsâ€"melons, blueberries, things like thatâ€"can mop up the free radicals that may speed up graying. There's also evidence that smokers can face early graying, likely due to the same free-radical formation."

Why do pregnant women have such lush hair? "Our hair develops in three stages: growing, transitioning, and resting, i.e., shedding. In pregnancy, the hair goes into a prolonged transitioning phase. Instead of shedding, the hairs stay put on the head. Now, this all comes to a crashing end three or four months after childbirth, when the hair starts to fall out dramatically. But that's nothing to worry aboutâ€"your hair will return to normal in six months to a year. If it doesn't, there may be an underlying medical problem, like thyroid disease or female pattern hair loss, which can be treated."

What happens during menopause? "Normal estrogen production drops off and unmasks the underlying androgens, or male hormones. Unmitigated, these androgens then wreak havoc on the hair follicles of the face and scalp. Have you ever seen those little old ladies with hairs on their chins? That's what can happen, as well as general hair loss and thinning. The same medicines we use for female pattern hair lossâ€"topical minoxidil and spironolactone, a diuretic used off-labelâ€"are helpful for these."

Any new treatments on the horizon? "The next medical therapy is Latisse, which is currently approved for eyelash thickening but is now in clinical trials for regrowing hair on the head. And hair-growth lasers. For a long time, the marketing was ahead of the data, but we're getting more evidence on a microscopic level that low-level light can grow hair. And more women are being put on Propecia with good results, although I doubt it will be approved by the FDA because of the risk of birth defects."

PHOTO: STOCKSY

How to age like a supermodel:

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Tuesday

Expert Q & A: Hormone Therapy for Anti-Aging - WGN-TV

Dr. Alex breaks down hormone therapy

Dr. Alex breaks down hormone therapy

Dr. Alex Paziotapulos is an expert in all things anti-aging, including hormone therapy. We sat down with him down to learn more.

LHC: What is hormone therapy?

Dr. Alex: Hormone therapy basically is replacing the natural hormones in your body, anything from the hormones from your adrenal glands like cortisol to your thyroid gland, to your estrogens, your progesterone, your testosterone, your DHEA, all these things. Hormones can fluctuate because of aging, stress levels, hormones can fluctuate because of lack of exercise, it can fluctuate from your diet. If you wait until you feel symptoms of hormones getting out of balance, you’ve waited a little bit too long.

LHC: How does hormone replacement or hormone therapy relate to anti-aging?

Dr. Alex: This natural hormone replacement helps combat many of the signs we generally associate with aging. with thinking, it helps reduce chances for cancer, for cardiovascular disease, for bone loss, for muscle loss.

LHC: How is hormone therapy actually administered? What does this actually look like?

It depends on the hormone. Thyroid you take by mouth, let’s say I had to give you some progesterone, I could do that through a topical cream. Testosterone we do through a pellet.

LHC: What’s a pellet?

Dr. Alex: I’ll show you! (See video below)

Check out the full story below, where host Jane Monzures get’s a full hormone therapy workup, and we spend some time with a patient of Dr. Alex who has seen huge benefits from hormone therapy.

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Monday

Will Anti-Aging Drugs Lead To A Brave New World? - Forbes

Ponce de León’s Fountain of Youth may soon be more than just a myth. According to Aubrey de Grey, a leading anti-aging researcher, there is likely a person alive today who will be immune to aging.  This optimism stems from the promising field of longevity research, which has shed its reputation as a quackery-ridden fringe science. If clinical trials of anti-aging drugs prove successful, it would utterly transform society in far-reaching ways. Could today’s generations live to see a world where 100 is the new 60?

There has been a growing push to examine the basic molecular processes behind aging and find ways to counteract them. Some treatments already exist as on-label drugs for other conditions, while others are experimental. The goal is to target aging itself as a major risk factor for the chronic diseases that cut lives short. “Drugs that lengthen health span,” The Atlantic proclaims, “are becoming to medical researchers what vaccines and antibiotics were to previous generations in the lab: their grail.”

Of all these possibilities, rapamycin has emerged as the most promising. It inhibits a gene called mTOR, which switches the body’s resources from “growth” to a more stress-resistant “maintenance” mode. This reflex taps into the same biological processes triggered by “caloric restriction,” a faminelike diet that, while known to reliably extend life span in a variety of organisms, would basically require humans to starve themselves. In a study funded by the National Institutes of Health, male and female mice given rapamycin in late middle age lived 9 percent and 14 percent longer, respectively, than untreated mice. As Businessweek explains, this is roughly equivalent to giving 60-year-old women a drug that enables them to live to 95.

What’s more, rapamycin has also produced encouraging results in human trials. A recent study of elderly patients found that small doses of a rapamycin-like drug improved their immune response to a flu vaccine by 20 percent, sating worries that it would suppress immune response. Pharmaceutical companies large and small, from Novartis to Calico, are now pouring resources into a field Big Pharma has long viewed with suspicion.

A scientist examines human cells under a microscope. (Photo by Ted S. Warren via AP)

But many scientists remain unconvinced.The history of anti-aging research is littered with misfires. Rapamycin isn’t without side effects: In mice, it limited fertility and increased the likelihood of developing cataracts and diabetes. The last focus of such hype, the “red wine pill” resveratrol, ended up failing in human trials. Everything from gold to vitamin C to growth hormones has been touted for its supposed life-extending propertiesâ€"often by hucksters.  And the fact that anti-aging drugs will likely first find their way to consumers as repurposed versions of existing medications does not add to their credibility.

In the eyes of these researchers, we’re no closer to finding an “elixir of life” than we were thousands of years ago. “There are no interventions that have been documented to slow, stop, or reverse aging in humans,” S. Jay Olshansky, a professor of public health at the University of Illinois at Chicago and a famed critic of life-extending treatments, tells Businessweek. “The batting average is zero.”

Even those who are optimistic caution that there is much scientists still don’t understand.A team of German researchers, for example, recently argued that the rapamycin’s effect on mice is largely due to the fact it inhibits tumors that represent their main cause of death. Moreover, even if it does slow aging, it might take decades for researchers to definitively establish its real effects. And in the end, these treatments might not make as much of a difference as the life-extending behaviors doctors have always recommended: exercise regularly and eat healthy food.

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Saturday

3 New Anti-Aging Treatments You Should Know About - Yahoo News

3 New Anti-Aging Treatments You Should Know About

Want plusher lips, defined cheekbones, or a stronger jawline? One of these fresh options could be right for you. (Photo: Shutterstock)

This month’s beauty innovator, dermatologist Whitney Bowe, M.D., spoke to Women’s Health about her favorite new anti-aging tweaks:

In 2015, women want to look like the best versions of themselvesâ€"not overly plumped or pinched. The good news is that among the cutting-edge tools and technologies we have to help take control of the aging process, there are now great options that give subtle, natural-looking results without a lot of downtime. In other words, small, minimally invasive treatments that can help stave off major wrinkles and sagging. Here are a few ways to look your most youthful and refreshed.

Plusher Lips
No more duck face! Restylane Silk is the first filler designed and specifically FDA-approved for not only the lips themselves but also the lines around the upper lip that can look like a bar code. Until now, they’ve been notoriously difficult to treat without making the mouth look swollen. With Restylane Silk, the plumping molecules are so much smaller than those in regular Restylane: Think sand grains versus pebbles. Lips don’t look bigger, just healthier and smoother. It costs approximately $750 and lasts about six months. Plus, since Restylane Silk has an anesthetic built right in, it’s more bearable than the lip injections of old.

RELATED: Get Big, Full Lips in Just 5 Steps

Defined Cheeks
Smile lines form when the bone, muscle, and fat of the cheeks thin outâ€"something that can happen as early as your late twenties. A new approach, Sculptra (a poly-L-lactic acid filler), is put into the upper cheekbone area to pull and lift the skin back into place. The catch: Since the filler triggers the body to replace lost collagen, results may not be obvious for about three months. With yearly maintenance, its effects last two to three years. Each vial costs around $900.

RELATED: The Anti-Aging Products You Should Be Using in Your Twenties, Thirties, and Forties

A Stronger Jawline
I rely on two devices to help shore up sagging skin under the jawline and at the bottom of the neck. The first, Ultherapy, uses ultrasound waves to tighten tissue that’s very deep down, above the muscle. It can be uncomfortable, like little zingers. Thermage CPT uses radio-frequency energyâ€"a different type of wavelength that doesn’t penetrate as deeply and is less painful. I find that Ultherapy works better for those with thicker, oily skin, and Thermage CPT for people with thin, delicate skin. The cost is around $2,000 to $3,000 for the lower face, jawline, and neck.

RELATED: 3 Sensitive Skin Mythsâ€"Busted!

â€"

Whitney Bowe, M.D. is a board-certified dermatologist in New York City and Briarcliff Manor, New York. She is the clinical assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai, and a clinical researcher for universities and cosmetic brands.

For more anti-aging tweaks, pick up the April 2015 issue of Women’s Health, on newsstands now.

More from Women’s Health:

The Silly Skin-Care Mistake You’re Making Each Morning

7 At-Home Fixes For Everyday Skin Problems

4 Reasons You’re Still Struggling with Acne

By Whitney Bowe

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Friday

Botox May Have Long-Lasting Anti-Aging Effects, Study Suggests - Healthline

Botox, an injection that paralyzes facial muscles to reduce the appearance of wrinkles, has a reputation for being the remedy of choice for vain starlets because it’s superficial and fleeting.

But a recent study suggests it may not be quite as superficial or as temporary.

The drug increases skin elasticity for the three to four months that it stays active, according to a Canadian study published in JAMA Facial Plastic Surgery by dermatologist Dr. James Bonaparte of the University of Ottawa and Dr. David Ellis of the University of Toronto.

“The initial theory for Botox was you paralyze the muscle, you then can’t make the wrinkle anymore because you can’t move. This is suggesting that there’s maybe more going on than just that, that you’re actually remodeling the skin to get rid of the wrinkle,” Bonaparte said.

Dermatologists had observed that even deep wrinkles that weren’t erased by Botox became less severe while it was active. Bonaparte has endeavored to measure the effect scientifically.

Read More: Some Tips on Anti-Aging Skin Care »

In the current study, he and Ellis used a Cutometer, a device that sucks the skin and measures how much it rebounds to its previous position. As we age, our skin becomes less elastic, recoiling about 30 percent less at age 70 than it does at age 20.

Flaccid skin makes us look older. It also makes the skin more prone to wrinkle.

The researchers found that when the effects of Botox were at their most powerful, the drug could increase elasticity by 30 percent. The effect peaked at two months and then waned before dropping off at four months.

The researchers tracked 43 women who were using Botox for the first time.

Related News: The 4 Best Vitamins for Your Skin »

Bonaparte’s earlier work on the same topic was met with criticism. Critics argued that what seemed to be elasticity could simply be swelling as a result of the injury from injection. As the skin heals from injury it draws in more water and becomes more elastic for a week or two.

The current study ruled that out by showing that injury resulted in a different pattern of resistance to the suction.

“Botox might be doing two things, one to the muscle one to the skin,” Bonaparte said.

If indeed Botox makes the skin more elastic, it may also help prevent the formation of wrinkles. That could expand the market for cosmetic injections significantly. More than 6.6 million Americans underwent treatment with Botox or a similar drug last year, according to the American Society of Plastic Surgeons.

Bonaparte, who also works in private practice, performs Botox injections for a fee. His study was funded by Allergan, the pharmaceutical company that makes Botox. All of the research to date on the potential anti-aging effects of Botox has been funded by Allergan, Bonaparte said.

Two other products, Dysport and Xeomin, can also legally be used to mute the furrow between eyebrows. Like Botox, they are derived from the naturally occurring botulinum toxin. Only Botox has the approval of the Food and Drug Administration for use on crow’s feet, but the others are often used off-label.

“There’s not reason to believe the other drugs wouldn’t have the same effect,” Bonaparte said.

To nail down exactly how the botulinum toxins ramp up elasticity, the next step will be to remove small bits of skin from participants before and after the procedures.

Read More: Get the Facts on Skin Disorders »

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Rob Lowe's New Anti-Aging Skincare Line Promises Timeless Handsomeness - The Frisky

I love Rob Lowe. He strikes me as the kind of guy who punctuates every sentence with “We have fun here!” He probably claps people on the shoulder a little too hard, smiling impishly, eyes a-twinkling. (Apparently, Rashida Jones once described him as a “benevolent narcissist,” which has the ring of truth.)

In keeping with his “relatable and earnest, but just vain enough to keep it interesting” celebrity #brand, Rob Lowe is launching a skincare line! It’s called PROFILE™, and it launches this week at Profile4men.com.

Is it a skincare line for men? Yes, it is for men: “This is not a repackaged women’s line with macho print,” Lowe explained to Women’s Wear Daily. “This is formulated specifically for men’s skin, which is up to 30 percent thicker than women’s skin.”

And who designed PROFILE™? Rob Lowe did: “The thing I really want people to understand is that I built this line from the ground up. …I’m not the celebrity endorser, I’m not the face of the product. I’m the developer of it.”

In an interview with The Cut, Lowe revealed some of his own health and beauty secrets, including wearing a sleep mask during his commuteâ€"not while driving! Rob Lowe has a driver, thank youâ€"and sticking to a high-protein “Paleo” breakfast. (In the same interview he discussed his “dadbod” obsession.)

Whatever Rob Lowe is doing, it’s working: he’s 51 somehow.

PROFILEâ„¢ will initially launch with five products, including cleanser, aftershave, and one of those anti-aging rollerball thingies for around the eye area. Still in the works: a moisturizing sunscreen. Besides being available at Profile4Men.com, the skincare line is also slated to appear in 60 Nordstroms.

[Today]

[Women's Wear Daily]

[The Cut]

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Thursday

Anti-aging drug may be just 5 years away - Economic Times

LONDON: A new anti-aging drug may be just five years away , say scientists who have identified the role of an enzyme in muscle wasting and associated age-related problems.
Researchers at the University of Birmingham believe that inhibiting the enzyme could hold the key to developing ways of preventing, or reversing, the adverse effects of aging.

The research is a significant step in understanding the role played by the enzyme 11beta-HSD1 in the degenerative effects of aging -including sarcopenia (age related muscle wasting).

Researchers claim the anti-aging drug could be available to the general public within the next five years. The expression of 11beta-HSD1, responsible for activating the steroid hormone cortisol, was increased in the muscles of older females.

About 134 healthy volunteers, aged between 20-80, underwent physical and biochemical tests at a clinical research facility. The findings show that expression of 11beta-HSD1 in skeletal muscles is increased 2.72-fold in women over 60 years of age, compared to those aged between 20 and 40. In male participants, no difference was seen.

"As yet, we don't know why it appears to only occur in women, it is obviously an interesting area for further research. We are planning to look at whether hormones such as estrogens could be involved," Dr Zaki HassanSmith, from the University of Birmingham, said. The researchers wanted to investigate novel ways of increasing healthy life span -the years in which people can maintain active lifestyles without the debilitating impact of muscle wasting.

"Looking at this particular enzyme seemed like an intriguing way forward. We knew how it works in relation to Cushing's Syndrome, which is characterised by similar symptoms, and thought it would be worthwhile applying what we knew to the aging population," said Hassan-Smith.

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